Targeted modulation of alternative splicing by TALE-directed chromatin editing
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F15%3A00454301" target="_blank" >RIV/68378050:_____/15:00454301 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Targeted modulation of alternative splicing by TALE-directed chromatin editing
Original language description
To reveal how local chromatin modulates the splicing outcome we developed a new method based on Transcription Activator-Like Effector Nuclease (TALEN) technology. We replaced the nuclease domain with chromatin modifying domain and tested how TALE based targeting of histone methyltransferases and a demethylase influences splicing of the targeted exon.
Czech name
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Czech description
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Classification
Type
O - Miscellaneous
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GBP305%2F12%2FG034" target="_blank" >GBP305/12/G034: Centre for RNA Biology</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů