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Sculpting the Transcriptome During the Oocyte-to-Embryo Transition in Mouse

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F15%3A00455879" target="_blank" >RIV/68378050:_____/15:00455879 - isvavai.cz</a>

  • Result on the web

    <a href="http://dx.doi.org/10.1016/bs.ctdb.2015.06.004" target="_blank" >http://dx.doi.org/10.1016/bs.ctdb.2015.06.004</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/bs.ctdb.2015.06.004" target="_blank" >10.1016/bs.ctdb.2015.06.004</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Sculpting the Transcriptome During the Oocyte-to-Embryo Transition in Mouse

  • Original language description

    In mouse, the oocyte-to-embryo transition entails converting a highly differentiated oocyte to totipotent blastomeres. This transition is driven by degradation of maternal mRNAs, which results in loss of oocyte identity, and reprogramming of gene expression during the course of zygotic gene activation, which occurs primarily during the two-cell stage and confers blastomere totipotency. Full-grown oocytes are transcriptionally quiescent and mRNAs are remarkably stable in oocytes due to the RNA-binding protein MSY2, which stabilizes mRNAs, and low activity of the 5' and 3' RNA degradation machinery. Oocyte maturation initiates a transition from mRNA stability to instability due to phosphorylation of MSY2, which makes mRNAs more susceptible to the RNA degradation machinery, and recruitment of dormant maternal mRNAs that encode for critical components of the 5' and 3' RNA degradation machinery. Small RNAs (miRNA, siRNA, and piRNA) play little, if any, role in mRNA degradation that occurs d

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    EB - Genetics and molecular biology

  • OECD FORD branch

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2015

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Current Topics in Developmental Biology

  • ISSN

    0070-2153

  • e-ISSN

  • Volume of the periodical

    113

  • Issue of the periodical within the volume

    Jul 29

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    45

  • Pages from-to

    305-349

  • UT code for WoS article

    000370507900009

  • EID of the result in the Scopus database