Sculpting the Transcriptome During the Oocyte-to-Embryo Transition in Mouse
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F15%3A00455879" target="_blank" >RIV/68378050:_____/15:00455879 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/bs.ctdb.2015.06.004" target="_blank" >http://dx.doi.org/10.1016/bs.ctdb.2015.06.004</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/bs.ctdb.2015.06.004" target="_blank" >10.1016/bs.ctdb.2015.06.004</a>
Alternative languages
Result language
angličtina
Original language name
Sculpting the Transcriptome During the Oocyte-to-Embryo Transition in Mouse
Original language description
In mouse, the oocyte-to-embryo transition entails converting a highly differentiated oocyte to totipotent blastomeres. This transition is driven by degradation of maternal mRNAs, which results in loss of oocyte identity, and reprogramming of gene expression during the course of zygotic gene activation, which occurs primarily during the two-cell stage and confers blastomere totipotency. Full-grown oocytes are transcriptionally quiescent and mRNAs are remarkably stable in oocytes due to the RNA-binding protein MSY2, which stabilizes mRNAs, and low activity of the 5' and 3' RNA degradation machinery. Oocyte maturation initiates a transition from mRNA stability to instability due to phosphorylation of MSY2, which makes mRNAs more susceptible to the RNA degradation machinery, and recruitment of dormant maternal mRNAs that encode for critical components of the 5' and 3' RNA degradation machinery. Small RNAs (miRNA, siRNA, and piRNA) play little, if any, role in mRNA degradation that occurs d
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Current Topics in Developmental Biology
ISSN
0070-2153
e-ISSN
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Volume of the periodical
113
Issue of the periodical within the volume
Jul 29
Country of publishing house
US - UNITED STATES
Number of pages
45
Pages from-to
305-349
UT code for WoS article
000370507900009
EID of the result in the Scopus database
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