Development of Soft Tissue Sarcomas in Ribosomal Proteins L5 and S24 Heterozygous Mice

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F16%3A00455741" target="_blank" >RIV/68378050:_____/16:00455741 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.7150/jca.13292" target="_blank" >http://dx.doi.org/10.7150/jca.13292</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.7150/jca.13292" target="_blank" >10.7150/jca.13292</a>

Result language
angličtina
Original language name
Development of Soft Tissue Sarcomas in Ribosomal Proteins L5 and S24 Heterozygous Mice
Original language description
Diamond-Blackfan anemia (DBA) is an inherited bone marrow failure syndrome associated with ribosomal protein (RP) gene mutations. Recent studies have also demonstrated an increased risk of cancer predisposition among DBA patients. In this study, we report the formation of soft tissue sarcoma in the Rpl5 and Rps24 heterozygous mice. Our observation suggests that even though one wild-type allele of the Rpl5 or Rps24 gene prevents anemia in these mice, it still predisposes them to cancer development.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Project
<a href="/en/project/LK21307" target="_blank" >LK21307: C/EBPg in normal hematopoiesis and acute myeloid leukemia: identification of the molecular mechanisms involved in cellular transformation</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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