Interferon gamma/NADPH oxidase defence system in immunity and cancer

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F16%3A00455802" target="_blank" >RIV/68378050:_____/16:00455802 - isvavai.cz</a>
Result on the web
<a href="https://www.tandfonline.com/doi/full/10.1080/2162402X.2015.1080416" target="_blank" >https://www.tandfonline.com/doi/full/10.1080/2162402X.2015.1080416</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1080/2162402X.2015.1080416" target="_blank" >10.1080/2162402X.2015.1080416</a>

Result language
angličtina
Original language name
Interferon gamma/NADPH oxidase defence system in immunity and cancer
Original language description
As a part of cellular pathogen defence, IFNγ triggers induction of NADPH oxidase NOX2, which produces superoxide into phagosomes of immune cells. Recent data show that a similar mechanism can also operate in IFNγ-mediated anti-cancer control. IFNγ is capable of inducing expression of constitutively active NADPH oxidase NOX4 in tumour cells leading to generation of reactive oxygen species damaging DNA, activation of DNA damage response and cell cycle arrest/premature cellular senescence.
Czech name
—
Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10601 - Cell biology

Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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