A systematic computational analysis of the rRNA-3 ' UTR sequence complementarity suggests a regulatory mechanism influencing post-termination events in metazoan translation
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F16%3A00463032" target="_blank" >RIV/68378050:_____/16:00463032 - isvavai.cz</a>
Alternative codes found
RIV/61388971:_____/16:00463032
Result on the web
<a href="http://dx.doi.org/10.1261/rna.056119.116" target="_blank" >http://dx.doi.org/10.1261/rna.056119.116</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1261/rna.056119.116" target="_blank" >10.1261/rna.056119.116</a>
Alternative languages
Result language
angličtina
Original language name
A systematic computational analysis of the rRNA-3 ' UTR sequence complementarity suggests a regulatory mechanism influencing post-termination events in metazoan translation
Original language description
Nucleic acid sequence complementarity underlies many fundamental biological processes. Although first noticed a long time ago, sequence complementarity between mRNAs and ribosomal RNAs still lacks a meaningful biological interpretation. Here we used statistical analysis of large-scale sequence data sets and high-throughput computing to explore complementarity between 18S and 28S rRNAs and mRNA 3' UTR sequences. By the analysis of 27,646 full-length 3' UTR sequences from 14 species covering both protozoans and metazoans, we show that the computed 18S rRNA complementarity creates an evolutionarily conserved localization pattern centered around the ribosomal mRNA entry channel, suggesting its biological relevance and functionality.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EE - Microbiology, virology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GBP305%2F12%2FG034" target="_blank" >GBP305/12/G034: Centre for RNA Biology</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
R N A
ISSN
1355-8382
e-ISSN
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Volume of the periodical
22
Issue of the periodical within the volume
7
Country of publishing house
US - UNITED STATES
Number of pages
9
Pages from-to
957-967-957-967
UT code for WoS article
000378068900002
EID of the result in the Scopus database
2-s2.0-84975041736