On board a raft or boat in the retrovirus sea
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F16%3A00471923" target="_blank" >RIV/68378050:_____/16:00471923 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1073/pnas.1602317113" target="_blank" >http://dx.doi.org/10.1073/pnas.1602317113</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1073/pnas.1602317113" target="_blank" >10.1073/pnas.1602317113</a>
Alternative languages
Result language
angličtina
Original language name
On board a raft or boat in the retrovirus sea
Original language description
This article summarizes the essential steps in understanding the chicken Rous sarcoma virus (RSV) genome association with a nonpermissive rodent host cell genome. This insight was made possible by in-depth study of RSV-transformed rat XC cells, which were called virogenic because they indefinitely carry virus genetic information in the absence of any infectious virus production. However, the virus was rescued by association of XC cells with chicken fibroblasts, allowing cell fusion between both partners. This and additional studies led to the interpretation that the RSV genome gets integrated into the host cell genome as a provirus. Study of additional rodent virogenic cell lines provided evidence that the transcript of oncogene v-src can be transmitted to other retroviruses and produce cell transformation by itself. As discussed in the text, two main questions related to nonpermissiveness to retrovirus infection remain to be solved. The first is changes in the retrovirus envelope gene allowing virus entry into a nonpermissive cell. The second is the nature of the permissive cell functions required by the nonpermissive cell to ensure infectious virus production. Both lines of investigation are being pursued.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GA15-22207S" target="_blank" >GA15-22207S: Analysis of Rous sarcoma virus replication blocks in non-permissive cells and characterization of factors contributing to virus rescue</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Proceedings of the National Academy of Sciences of the United States of America
ISSN
0027-8424
e-ISSN
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Volume of the periodical
113
Issue of the periodical within the volume
15
Country of publishing house
US - UNITED STATES
Number of pages
5
Pages from-to
3927-3931
UT code for WoS article
000373762400027
EID of the result in the Scopus database
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