Proviral integrations of MAV-2 retrovirus in the chicken genome

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F12%3A00377759" target="_blank" >RIV/68378050:_____/12:00377759 - isvavai.cz</a>
Result on the web
<a href="http://mav-cis.img.cas.cz/results.html" target="_blank" >http://mav-cis.img.cas.cz/results.html</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Proviral integrations of MAV-2 retrovirus in the chicken genome
Original language description
The table of proviral insertion sites of MAV-2 retrovirus in the chicken genome. Myeloblastosis-associated virus 2 (MAV-2) is a chicken oncogenic retrovirus with the unique ability to induce development of various types of experimental tumors including nephroblastoma, angiosarcoma of lungs, liver and heart, liver carcinoma, cholangiocarcinoma and other rare tumor types. Genes found to be recurrently hit by clonal insertion of the MAV-2 provirus in independent clonal tumors are thought to be cancer genesand their deregulation/mutation is responsible for transformation of the host cell. We used a chicken MAV-2-based model of insertional mutagenesis to identify more than hundred of candidate genes whose deregulation could be responsible for the formationof chicken nephroblastoma, lung angiosarcoma, liver angiosarcoma, hepatocarcinoma and cholangiocarcinoma and for transformation in vitro. Detailed study of the cooperation of MAV-2 insertional mutagenesis and promotional effects of stray
Czech name
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Czech description
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Project
<a href="/en/project/GA301%2F09%2F1727" target="_blank" >GA301/09/1727: Large-scale identification of genes responsible for the formation of solid tumours</a><br>
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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