Chicken models of retroviral insertional mutagenesis

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F11%3A00378894" target="_blank" >RIV/68378050:_____/11:00378894 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1007/978-1-4419-7656-7" target="_blank" >http://dx.doi.org/10.1007/978-1-4419-7656-7</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/978-1-4419-7656-7" target="_blank" >10.1007/978-1-4419-7656-7</a>

Result language
angličtina
Original language name
Chicken models of retroviral insertional mutagenesis
Original language description
The introductory part summarizes published results of searching for cancer-related genes obtained using chicken models of insertional mutagenesis and presents new views of mechanisms by which integrated proviruses deregulate host gene expression. The major part of the chapter is devoted to the most advanced model based on MAV-2 retrovirus that has been elaborated recently by the authors. So far the model allowed identification of genes participating in the formation of nephroblastomas, lung and liver hemangiosarcomas, liver carcinomas and cholangiocarcinomas. Most of these tumor types were induced with the help of the new phenomenon discovered recently by the authors: non-tumor cells released into the blood circulation and passing further into tissuesstrongly promote the formation of a tumor from latent malignant cells primed by MAV-2 insertional mutagenesis. The data described in the chapter are up-to-date and include the newest results of the authors that has not been published yet.
Czech name
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Czech description
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Project
<a href="/en/project/GA301%2F09%2F1727" target="_blank" >GA301/09/1727: Large-scale identification of genes responsible for the formation of solid tumours</a><br>
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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