Exploring avian cancer genome with insertional mutagenesis screens using myeloblastosis associated viruses

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F19%3A00523240" target="_blank" >RIV/68378050:_____/19:00523240 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Exploring avian cancer genome with insertional mutagenesis screens using myeloblastosis associated viruses
Original language description
We have established a new model for studying cancer genetics based on insertional mutagenesis by chicken retrovirus myeloblastosis-associated virus-2 (MAV-2) and tumor-promoting agents that target tumorigenesis into individual organs. Using high-performance iPCR we analyzed a large number of chicken tumors, pinpointed common provirus-insertion sites and associated them with candidate cancer genes. So far, we have defined the principal oncogenes driving formation of chicken nephroblastomas (FOXP1, PLAG1, TWIST or HRAS), lung hemangiosarcomas (FRK), liver hemangiosarcomas (HRAS), hepatocarcinomas (EGFR), and cholangiocarcinomas (HGFR or MST1R)(1-4). All of them are now proven human oncogenes, in three cases (TWIST, FOXP1, FRK), our findings preceded the discovery of their involvement in human tumors. This shows that non-mouse species are good alternative models for studying oncogenesis with outcomes applicable to human medicine.n
Czech name
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Czech description
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Project
<a href="/en/project/LO1419" target="_blank" >LO1419: Biomodels for Health - Center for model organisms</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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