A Eukaryote without a Mitochondrial Organelle

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F16%3A00486310" target="_blank" >RIV/68378050:_____/16:00486310 - isvavai.cz</a>

Alternative codes found

RIV/61988987:17310/16:A1701KTI RIV/00216208:11310/16:10324105

Result on the web

<a href="http://dx.doi.org/10.1016/j.cub.2016.03.053" target="_blank" >http://dx.doi.org/10.1016/j.cub.2016.03.053</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.cub.2016.03.053" target="_blank" >10.1016/j.cub.2016.03.053</a>

Result language

angličtina

Original language name

A Eukaryote without a Mitochondrial Organelle

Original language description

The presence of mitochondria and related organelles in every studied eukaryote supports the view that mitochondria are essential cellular components. Here, we report the genome sequence of a microbial eukaryote, the oxymonad Monocercomonoides sp., which revealed that this organism lacks all hallmark mitochondrial proteins. Crucially, the mitochondrial iron-sulfur cluster assembly pathway, thought to be conserved in virtually all eukaryotic cells, has been replaced by a cytosolic sulfur mobilization system (SUF) acquired by lateral gene transfer from bacteria. In the context of eukaryotic phylogeny, our data suggest that Monocercomonoides is not primitively amitochondrial but has lost the mitochondrion secondarily. This is the first example of a eukaryote lacking any form of a mitochondrion, demonstrating that this organelle is not absolutely essential for the viability of a eukaryotic cell.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10605 - Developmental biology

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Current Biology

ISSN

0960-9822

e-ISSN

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Volume of the periodical

26

Issue of the periodical within the volume

10

Country of publishing house

GB - UNITED KINGDOM

Number of pages

11

Pages from-to

1274-1284

UT code for WoS article

000376466000022

EID of the result in the Scopus database

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