Model of obesity and Diabetes melitus II help genetic modified mouses with insertion of surplus copies for SGIP1

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F16%3A00488007" target="_blank" >RIV/68378050:_____/16:00488007 - isvavai.cz</a>

Alternative codes found

RIV/68378050:_____/16:00523408

Result on the web

—

DOI - Digital Object Identifier

—

Result language

čeština

Original language name

Model obesity a Diabetes mellitus 2. typu pomocí geneticky modifikovaných myší s insercí nadbytečných kopií genu pro SGIP1

Original language description

Many diseases of the nervous system, including central regulation of metabolic homeostasis, are accompanied by alterations in synaptic functions. Synaptic plasticity mediated by the endogenous cannabinoid system involves the activation of the Cannabinoid Receptor 1 (CB1R). The principles of CB1R signaling must be understood in detail for its therapeutic exploration. nnSrc homology 3-domain growth factor receptor-bound 2-like (endophilin) interacting protein 1 (SGIP1) is a novel Cannabinoid receptor (CB1R) interacting partner. SGIP1 prevents the endocytosis of the activated CB1R and signaling via the CB1R is altered as a consequence of the receptor’s interaction with SGIP1 in a biased manner. While the CB1R mediated Gi/o-protein coupling is influenced by SGIP1 only marginally, the arrestin-associated signaling is changed profoundly. The projected studies are aimed at deciphering the consequences of SGIP1 interaction with the CB1R on its signaling at the molecular and cellular levels. nnSGIP1 overexpression in Psamomys Obesus (Israeli sand rat) leads to an energy regulation imbalance resulting in obesity. Interestingly, the animals in their original ecosystem do not become obese. The obesity occurs only in when kept in cages with enough source of energy. Thus, in a way, this animal model is far closest to the situation of so called “civilization disease” characterized by lack of movement, inappropriate calorical input with all consequences known as metabolic syndrome.n

Czech name

Model obesity a Diabetes mellitus 2. typu pomocí geneticky modifikovaných myší s insercí nadbytečných kopií genu pro SGIP1

Czech description

Many diseases of the nervous system, including central regulation of metabolic homeostasis, are accompanied by alterations in synaptic functions. Synaptic plasticity mediated by the endogenous cannabinoid system involves the activation of the Cannabinoid Receptor 1 (CB1R). The principles of CB1R signaling must be understood in detail for its therapeutic exploration. nnSrc homology 3-domain growth factor receptor-bound 2-like (endophilin) interacting protein 1 (SGIP1) is a novel Cannabinoid receptor (CB1R) interacting partner. SGIP1 prevents the endocytosis of the activated CB1R and signaling via the CB1R is altered as a consequence of the receptor’s interaction with SGIP1 in a biased manner. While the CB1R mediated Gi/o-protein coupling is influenced by SGIP1 only marginally, the arrestin-associated signaling is changed profoundly. The projected studies are aimed at deciphering the consequences of SGIP1 interaction with the CB1R on its signaling at the molecular and cellular levels. nnSGIP1 overexpression in Psamomys Obesus (Israeli sand rat) leads to an energy regulation imbalance resulting in obesity. Interestingly, the animals in their original ecosystem do not become obese. The obesity occurs only in when kept in cages with enough source of energy. Thus, in a way, this animal model is far closest to the situation of so called “civilization disease” characterized by lack of movement, inappropriate calorical input with all consequences known as metabolic syndrome.n

Type

G_funk - Functional sample

CEP classification

—

OECD FORD branch

30103 - Neurosciences (including psychophysiology)

Project

<a href="/en/project/TG01010066" target="_blank" >TG01010066: Applied molecular genetics and biology - IMG</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Internal product ID

Gama-1

Numerical identification

—

Technical parameters

Jedná se o linii geneticky modifikované myši. Komerční zhodnocení bylo zahájeno, nicméně konkrétní odběratel zatím není.

Economical parameters

Jedná se o myší model jednoho z nejrozšířenější poruchy metabolismu. Existují myší modely používané pro vývoj léků, nicméně každý má limitace. Výsledek tak představuje možnost dalšího ověření při vývoji léků a léčebných postupů diabetu mellitus II. Typu, onemocnění jež postihuje okolo desetiny populace.

Application category by cost

—

Owner IČO

68378050

Owner name

Ústav molekulární genetiky AV ČR, v.v

Owner country

CZ - CZECH REPUBLIC

Usage type

O - Doposud nevyužívaný výsledek

Licence fee requirement

—

Web page

—