A minimum number of autoimmune T cells to induce autoimmunity?

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F17%3A00477930" target="_blank" >RIV/68378050:_____/17:00477930 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.cellimm.2017.03.002" target="_blank" >http://dx.doi.org/10.1016/j.cellimm.2017.03.002</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.cellimm.2017.03.002" target="_blank" >10.1016/j.cellimm.2017.03.002</a>

Result language
angličtina
Original language name
A minimum number of autoimmune T cells to induce autoimmunity?
Original language description
While autoimmune T cells are present in most individuals, only a minority of the population suffers from an autoimmune disease. To better appreciate the limits of T cell tolerance, we carried out experiments to determine how many autoimmune T cells are required to initiate an experimental autoimmune disease. Variable numbers of autoimmune OT-I T cells were transferred into RIP-OVA mice, which were injected with antigen-loaded DCs in a single footpad, this restricted T cell priming to a few OT-I T cells that are present in the draining popliteal lymph node. Using selective plane illumination microscopy (SPIM) we counted the number of OT-I T cells present in the popliteal lymph node at the time of priming. Analysis of our data suggests that a single autoimmune T cell cannot induce an experimental autoimmune disease, but a 'quorum' of 2-5 autoimmune T cells clearly has this capacity. (C) 2017 Elsevier Inc. All rights reserved.
Czech name
—
Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30102 - Immunology

Project
<a href="/en/project/GJ16-09208Y" target="_blank" >GJ16-09208Y: T cell receptor signaling and fate decisions made by peripheral T cells in homeostasis and during inflammation</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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