Isoprenoids responsible for protein prenylation modulate the biological effects of statins on pancreatic cancer cells

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F17%3A00486290" target="_blank" >RIV/68378050:_____/17:00486290 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/17:10367236 RIV/00064165:_____/17:10367236
Result on the web
<a href="http://dx.doi.org/10.1186/s12944-017-0641-0" target="_blank" >http://dx.doi.org/10.1186/s12944-017-0641-0</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1186/s12944-017-0641-0" target="_blank" >10.1186/s12944-017-0641-0</a>

Result language
angličtina
Original language name
Isoprenoids responsible for protein prenylation modulate the biological effects of statins on pancreatic cancer cells
Original language description
Background: Statin treatment of hypercholesterolemia is accompanied also with depletion of the mevalonate intermediates, including farnesyl pyrophosphate (FPP) and geranylgeranyl pyrophosphate (GGPP) necessary for proper function of small GTPases. These include Ras proteins, prevalently mutated in pancreatic cancer. In our study, we evaluated the effect of three key intermediates of the mevalonate pathway on GFP-K-Ras protein localization and the gene expression profile in pancreatic cancer cells after exposure to individual statins.
Czech name
—
Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10601 - Cell biology

Project
<a href="/en/project/NT13112" target="_blank" >NT13112: Studies of anticancer effects of statins</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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