Residual Cdk1/2 activity after DNA damage promotes senescence

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F17%3A00486699" target="_blank" >RIV/68378050:_____/17:00486699 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1111/acel.12588" target="_blank" >http://dx.doi.org/10.1111/acel.12588</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/acel.12588" target="_blank" >10.1111/acel.12588</a>

Result language

angličtina

Original language name

Residual Cdk1/2 activity after DNA damage promotes senescence

Original language description

In response to DNA damage, a cell can be forced to permanently exit the cell cycle and become senescent. Senescence provides an early barrier against tumor development by preventing proliferation of cells with damaged DNA. By studying single cells, we show that Cdk activity persists after DNA damage until terminal cell cycle exit. This low level of Cdk activity not only allows cell cycle progression, but also promotes cell cycle exit at a decision point in G2 phase. We find that residual Cdk1/2 activity is required for efficient p21 production, allowing for nuclear sequestration of Cyclin B1, subsequent APC/C-Cdh1-dependent degradation of mitotic inducers and induction of senescence. We suggest that the same activity that triggers mitosis in an unperturbed cell cycle enforces senescence in the presence of DNA damage, ensuring a robust response when most needed.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10608 - Biochemistry and molecular biology

Project

<a href="/en/project/GA13-18392S" target="_blank" >GA13-18392S: Dynamics of DNA damage response in cells</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

AGING CELL

ISSN

1474-9726

e-ISSN

—

Volume of the periodical

16

Issue of the periodical within the volume

3

Country of publishing house

GB - UNITED KINGDOM

Number of pages

10

Pages from-to

575-584

UT code for WoS article

000402426900016

EID of the result in the Scopus database

—