On the Possibility of an Early Evolutionary Origin for the Spliced Leader Trans-Splicing
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F17%3A00507107" target="_blank" >RIV/68378050:_____/17:00507107 - isvavai.cz</a>
Result on the web
<a href="https://link.springer.com/article/10.1007%2Fs00239-017-9803-y" target="_blank" >https://link.springer.com/article/10.1007%2Fs00239-017-9803-y</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00239-017-9803-y" target="_blank" >10.1007/s00239-017-9803-y</a>
Alternative languages
Result language
angličtina
Original language name
On the Possibility of an Early Evolutionary Origin for the Spliced Leader Trans-Splicing
Original language description
Trans-splicing is a process by which 5'- and 3'-ends of two pre-RNA molecules transcribed from different sites of the genome can be joined together to form a single RNA molecule. The spliced leader (SL) trans-splicing is mediated by the spliceosome and it allows the replacement of 5'-end of pre-mRNA by 5'(SL)-end of SL-RNA. This form of splicing has been observed in many phylogenetically unrelated eukaryotes. Either the SL trans-splicing (SLTS) originated in the last eukaryotic common ancestor (LECA) (or even earlier) and it was lost in most eukaryotic lineages, or this mechanism of RNA processing evolved several times independently in various unrelated eukaryotic taxa. The bioinformatic comparisons of SL-RNAs from various eukaryotic taxonomic groups have revealed the similarities of secondary structures of most SL-RNAs and a relative conservation of their splice sites (SSs) and Sm-binding sites (SmBSs). We propose that such structural and functional similarities of SL-RNAs are unlikely to have evolved repeatedly many times. Hence, we favor the scenario of an early evolutionary origin for the SLTS and multiple losses of SL-RNAs in various eukaryotic lineages.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Molecular Evolution
ISSN
0022-2844
e-ISSN
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Volume of the periodical
85
Issue of the periodical within the volume
1-2
Country of publishing house
US - UNITED STATES
Number of pages
9
Pages from-to
37-45
UT code for WoS article
000408952900005
EID of the result in the Scopus database
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