Interplay with the Mre11-Rad50-Nbs1 complex and phosphorylation by GSK3 beta implicate human B-Myb in DNA-damage signaling
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F17%3A00507504" target="_blank" >RIV/68378050:_____/17:00507504 - isvavai.cz</a>
Result on the web
<a href="https://www.nature.com/articles/srep41663" target="_blank" >https://www.nature.com/articles/srep41663</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/srep41663" target="_blank" >10.1038/srep41663</a>
Alternative languages
Result language
angličtina
Original language name
Interplay with the Mre11-Rad50-Nbs1 complex and phosphorylation by GSK3 beta implicate human B-Myb in DNA-damage signaling
Original language description
B-Myb, a highly conserved member of the Myb transcription factor family, is expressed ubiquitously in proliferating cells and controls the cell cycle dependent transcription of G2/M-phase genes. Deregulation of B-Myb has been implicated in oncogenesis and loss of genomic stability. We have identified B-Myb as a novel interaction partner of the Mre11-Rad50-Nbs1 (MRN) complex, a key player in the repair of DNA double strand breaks. We show that B-Myb directly interacts with the Nbs1 subunit of the MRN complex and is recruited transiently to DNA-damage sites. In response to DNA-damage B-Myb is phosphorylated by protein kinase GSK3 beta and released from the MRN complex. A B-Myb mutant that cannot be phosphorylated by GSK3 beta disturbs the regulation of pro-mitotic B-Myb target genes and leads to inappropriate mitotic entry in response to DNA-damage. Overall, our work suggests a novel function of B-Myb in the cellular DNA-damage signalling.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Scientific Reports
ISSN
2045-2322
e-ISSN
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Volume of the periodical
7
Issue of the periodical within the volume
January
Country of publishing house
GB - UNITED KINGDOM
Number of pages
14
Pages from-to
41663
UT code for WoS article
000393020000001
EID of the result in the Scopus database
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