Changing the threshold-Signals and mechanisms of mast cell priming

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F18%3A00494578" target="_blank" >RIV/68378050:_____/18:00494578 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1111/imr.12625" target="_blank" >http://dx.doi.org/10.1111/imr.12625</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/imr.12625" target="_blank" >10.1111/imr.12625</a>

Result language

angličtina

Original language name

Changing the threshold-Signals and mechanisms of mast cell priming

Original language description

Mast cells play a key role in allergy and other inflammatory diseases involving engagement of multivalent antigen with IgE bound to high-affinity IgE receptors (Fc epsilon RIs). Aggregation of Fc epsilon RIs on mast cells initiates a cascade of signaling events that eventually lead to degranulation, secretion of leukotrienes and prostaglandins, and cytokine and chemokine production contributing to the inflammatory response. Exposure to pro-inflammatory cytokines, chemokines, bacterial and viral products, as well as some other biological products and drugs, induces mast cell transition from the basal state into a primed one, which leads to enhanced response to IgE-antigen complexes. Mast cell priming changes the threshold for antigen-mediated activation by various mechanisms, depending on the priming agent used, which alone usually do not induce mast cell degranulation. In this review, we describe the priming processes induced in mast cells by various cytokines (stem cell factor, interleukins-4,6 and33), chemokines, other agents acting through G protein-coupled receptors (adenosine, prostaglandin E-2, sphingosine-1-phosphate, and beta-2-adrenergic receptor agonists), toll-like receptors, and various drugs affecting the cytoskeleton. We will review the current knowledge about the molecular mechanisms behind priming of mast cells leading to degranulation and cytokine production and discuss the biological effects of mast cell priming induced by several cytokines.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30200 - Clinical medicine

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Immunological Reviews

ISSN

0105-2896

e-ISSN

—

Volume of the periodical

282

Issue of the periodical within the volume

1

Country of publishing house

GB - UNITED KINGDOM

Number of pages

14

Pages from-to

73-86

UT code for WoS article

000424876400006

EID of the result in the Scopus database

—