The oocyte-to-embryo transition in mouse: past, present, and future

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F18%3A00495156" target="_blank" >RIV/68378050:_____/18:00495156 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1093/biolre/ioy013" target="_blank" >http://dx.doi.org/10.1093/biolre/ioy013</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1093/biolre/ioy013" target="_blank" >10.1093/biolre/ioy013</a>

Result language
angličtina
Original language name
The oocyte-to-embryo transition in mouse: past, present, and future
Original language description
The oocyte-to-embryo transition (OET) arguably initiates with formation of a primordial follicle and culminates with reprogramming of gene expression during the course of zygotic genome activation. This transition results in converting a highly differentiated cell, i.e. oocyte, to undifferentiated cells, i.e. initial blastomeres of a preimplantation embryo. A plethora of changes occur during the OET and include, but are not limited to, changes in transcription, chromatin structure, and protein synthesis, accumulation of macromolecules and organelles that will comprise the oocyte's maternal contribution to the early embryo, sequential acquisition of meiotic and developmental competence to name but a few. This review will focus on transcriptional and post-transcriptional changes that occur during OET in mouse because such changes are likely the major driving force for OET. We often take a historical and personal perspective, and highlight how advances in experimental methods often catalyzed conceptual advances in understanding the molecular bases for OET. We also point out questions that remain open and therefore represent topics of interest for future investigation.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10604 - Reproductive biology (medical aspects to be 3)

Project
<a href="/en/project/GBP305%2F12%2FG034" target="_blank" >GBP305/12/G034: Centre for RNA Biology</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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