NQO1*2 polymorphism predicts overall survival in MDS patients
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F19%3A00497048" target="_blank" >RIV/68378050:_____/19:00497048 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/19:10396071 RIV/00064165:_____/19:10396071
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/full/10.1111/bjh.15088" target="_blank" >https://onlinelibrary.wiley.com/doi/full/10.1111/bjh.15088</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/bjh.15088" target="_blank" >10.1111/bjh.15088</a>
Alternative languages
Result language
angličtina
Original language name
NQO1*2 polymorphism predicts overall survival in MDS patients
Original language description
NAD(P)H quinone dehydrogenase 1 (NQO1) is an enzyme that detoxifies quinones and reduces oxidative stress. The naturally occurring germline polymorphism of NQO1 (NQO1*2) with a cytosine–to-thymidine substitution at nucleotide position 609 of the NQO1 cDNA results in the loss of NQO1 activity and rapid degradation of the protein encoded by NQO1*2 due to an unstable structure. The loss of NQO1 activity can result into disease susceptibility and therapeutic response. Examining a cohort of 187 MDS patients we studied how the presence of NQO1*2 polymorphism affects the development and progression of MDS and assessed the correlation between NQO1*2 and the overall survival (OS, calculated from the date of diagnosis), presence of karyotypic abnormalities, and response to hypomethylating therapy in MDS patients. We found that the presence of NQO1*2 alleles is associated with higher probability of the development of MDS, faster disease progression, sensitivity to blood transfusion-provoked iron overload, and shorter expected OS.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30101 - Human genetics
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
British Journal of Haematology
ISSN
0007-1048
e-ISSN
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Volume of the periodical
184
Issue of the periodical within the volume
2
Country of publishing house
GB - UNITED KINGDOM
Number of pages
4
Pages from-to
305-308
UT code for WoS article
000455218700027
EID of the result in the Scopus database
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