Small molecule modulators of Wnt/β-catenin-driven gene expression
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F19%3A00502878" target="_blank" >RIV/68378050:_____/19:00502878 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Small molecule modulators of Wnt/β-catenin-driven gene expression
Original language description
The Wnt pathway represents an evolutionarily conserved signaling mechanism that governs transcriptional programs responsible for proper embryonic development and homeostasis of multiple adult organs. In healthy tissues, canonical -catenin-dependent Wnt signaling is indispensable for stem cell maintenance. In contrast, aberrant Wnt pathway activation underlies a number of diseases, most notably various types of solid cancers and leukemia. The Wnt signal-transducing cascade includes multiple components involved in the pathway regulation. In the past 20 years, great effort has been concentrated on discovering and characterizing these components. Additionally, many small molecule compounds that influence the Wnt signaling output have been identified. Wnt signaling inhibitors might be used for improved cancer therapy. On the other hand, as culture media constituents, the Wnt activators can support growth of adult stem cells in vitro. Both of these usages make search for modulators of Wnt signaling an attractive area of biomedical research. In this review, we summarize a number of compounds that were recently shown to effectively modulate Wnt/β-catenin signaling. As our team has identified some of these compounds, the review also focuses on experimental tools and methods used to identify and test small molecule inhibitors of Wnt signaling.
Czech name
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Czech description
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Classification
Type
C - Chapter in a specialist book
CEP classification
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OECD FORD branch
10601 - Cell biology
Result continuities
Project
<a href="/en/project/LO1220" target="_blank" >LO1220: CZ-OPENSCREEN: National infrastructure for chemical biology</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Book/collection name
Advances in Chemical Biology
ISBN
978-80-88011-03-3
Number of pages of the result
15
Pages from-to
2-19
Number of pages of the book
210
Publisher name
OPTIO CZ
Place of publication
Praha
UT code for WoS chapter
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