The Novel Avian Leukosis Virus Subgroup K Shares Its Cellular Receptor with Subgroup A
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F19%3A00510424" target="_blank" >RIV/68378050:_____/19:00510424 - isvavai.cz</a>
Result on the web
<a href="https://jvi.asm.org/content/93/17/e00580-19" target="_blank" >https://jvi.asm.org/content/93/17/e00580-19</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1128/JVI.00580-19" target="_blank" >10.1128/JVI.00580-19</a>
Alternative languages
Result language
angličtina
Original language name
The Novel Avian Leukosis Virus Subgroup K Shares Its Cellular Receptor with Subgroup A
Original language description
Avian leukosis virus subgroup K (ALV-K) is composed of newly emerging isolates, which, in sequence analyses, cluster separately from the well-characterized subgroups A, B, C, D, E, and J. However, it remains unclear whether ALV-K represents an independent ALV subgroup with regard to receptor usage, host range, and superinfection interference. In the present study, we examined the host range of the Chinese infectious isolate JS11C1, an ALV-K prototype, and we found substantial overlap of species that were either resistant or susceptible to ALV-A and JS11C1. Ectopic expression of the chicken tva gene in mammalian cells conferred susceptibility to JS11C1, while genetic ablation of the tva gene rendered chicken DF-1 cells resistant to infection by JS11C1. Thus, tva expression is both sufficient and necessary for JS11C1 entry. Receptor sharing was also manifested in superinfection interference, with preinfection of cells with ALV-A, but not ALV-B or ALV-J, blocking subsequent JS11C1 infection. Finally, direct binding of JS11C1 and Tva was demonstrated by preincubation of the virus with soluble Tva, which substantially decreased viral infectivity in susceptible chicken cells. Collectively, these findings indicate that JS11C1 represents a new and bona fide ALV subgroup that utilizes Tva for cell entry and binds to a site other than that for ALV-A.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10607 - Virology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Virology
ISSN
0022-538X
e-ISSN
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Volume of the periodical
93
Issue of the periodical within the volume
17
Country of publishing house
US - UNITED STATES
Number of pages
12
Pages from-to
e00580-19
UT code for WoS article
000480712100011
EID of the result in the Scopus database
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