Differentiation Induction as a Response to Irradiation in Neural Stem Cells In Vitro

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F19%3A00511740" target="_blank" >RIV/68378050:_____/19:00511740 - isvavai.cz</a>

Alternative codes found

RIV/61389005:_____/19:00509936 RIV/68407700:21340/19:00346037

Result on the web

<a href="https://www.mdpi.com/2072-6694/11/7/913" target="_blank" >https://www.mdpi.com/2072-6694/11/7/913</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/cancers11070913" target="_blank" >10.3390/cancers11070913</a>

Result language

angličtina

Original language name

Differentiation Induction as a Response to Irradiation in Neural Stem Cells In Vitro

Original language description

Radiotherapy plays a significant role in brain cancer treatment, however, the use of this therapy is often accompanied by neurocognitive decline that is, at least partially, a consequence of radiation-induced damage to neural stem cell populations. Our findings describe features that define the response of neural stem cells (NSCs) to ionizing radiation. We investigated the effects of irradiation on neural stem cells isolated from the ventricular-subventricular zone of mouse brain and cultivated in vitro. Our findings describe the increased transcriptional activity of p53 targets and proliferative arrest after irradiation. Moreover, we show that most cells do not undergo apoptosis after irradiation but rather cease proliferation and start a differentiation program. Induction of differentiation and the demonstrated potential of irradiated cells to differentiate into neurons may represent a mechanism whereby damaged NSCs eliminate potentially hazardous cells and circumvent the debilitating consequences of cumulative DNA damage.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10601 - Cell biology

Project

<a href="/en/project/LO1419" target="_blank" >LO1419: Biomodels for Health - Center for model organisms</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Cancers (Basel)

ISSN

2072-6694

e-ISSN

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Volume of the periodical

11

Issue of the periodical within the volume

7

Country of publishing house

CH - SWITZERLAND

Number of pages

13

Pages from-to

913

UT code for WoS article

000479322800024

EID of the result in the Scopus database

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