Nuclear Phosphoinositides-Versatile Regulators of Genome Functions
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F19%3A00521616" target="_blank" >RIV/68378050:_____/19:00521616 - isvavai.cz</a>
Result on the web
<a href="https://www.mdpi.com/2073-4409/8/7/649" target="_blank" >https://www.mdpi.com/2073-4409/8/7/649</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/cells8070649" target="_blank" >10.3390/cells8070649</a>
Alternative languages
Result language
angličtina
Original language name
Nuclear Phosphoinositides-Versatile Regulators of Genome Functions
Original language description
The many functions of phosphoinositides in cytosolic signaling were extensively studied, however, their activities in the cell nucleus are much less clear. In this review, we summarize data about their nuclear localization and metabolism, and review the available literature on their involvements in chromatin remodeling, gene transcription, and RNA processing. We discuss the molecular mechanisms via which nuclear phosphoinositides, in particular phosphatidylinositol (4,5)-bisphosphate (PI(4,5)P2), modulate nuclear processes. We focus on PI(4,5)P2's role in the modulation of RNA polymerase I activity, and functions of the nuclear lipid islets recently described nucleoplasmic PI(4,5)P2-rich compartment involved in RNA polymerase II transcription. In conclusion, the high impact of the phosphoinositide protein complexes on nuclear organization and genome functions is only now emerging and deserves further thorough studies.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10601 - Cell biology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Cells
ISSN
2073-4409
e-ISSN
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Volume of the periodical
8
Issue of the periodical within the volume
7
Country of publishing house
CH - SWITZERLAND
Number of pages
19
Pages from-to
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UT code for WoS article
000478902000041
EID of the result in the Scopus database
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