Gene Expression in Patients With Abdominal Aortic Aneurysm More Than Immunological Mechanisms Involved

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F19%3A00522800" target="_blank" >RIV/68378050:_____/19:00522800 - isvavai.cz</a>

Alternative codes found

RIV/00023884:_____/19:00008170

Result on the web

<a href="https://doi.org/10.33549/physiolres.933905" target="_blank" >https://doi.org/10.33549/physiolres.933905</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.33549/physiolres.933905" target="_blank" >10.33549/physiolres.933905</a>

Result language

angličtina

Original language name

Gene Expression in Patients With Abdominal Aortic Aneurysm More Than Immunological Mechanisms Involved

Original language description

Abdominal aortic aneurysm (AAA) is a serious condition of unclear pathogenesis and progression. Two samples were collected from 48 patients during AAA surgery. One sample was collected from the aneurysm, the other from the aneurysm proximal neck where the tissue did not exhibit any aneurysmal changes. Subsequently, gene expression profiles using microarrays (Illumina) were compared in RNA extracted from the samples. Overall, 2,185 genes were found to be upregulated and 2,100 downregulated, from which 158 genes had a different expression with FDR<0.05 (False Discovery Rate) and FC >= 2 (Fold Change). Of this number, 115 genes were over-expressed and 43 under-expressed. The analysis of the gene list based on their biological pathways revealed that the regulation of inflammation was mediated by chemokine and cytokine signaling pathways, the integrin signaling pathway, and T and B cell activation. Moreover, a change was identified in the expression of genes involved in both intercellular and intracellular signaling systems.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10608 - Biochemistry and molecular biology

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Physiological Research

ISSN

0862-8408

e-ISSN

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Volume of the periodical

68

Issue of the periodical within the volume

3

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

10

Pages from-to

385-394

UT code for WoS article

000476830200005

EID of the result in the Scopus database

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