The mannose 6-phosphate/insulin-like growth factor 2 receptor mediates plasminogen-induced efferocytosis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F19%3A00523092" target="_blank" >RIV/68378050:_____/19:00523092 - isvavai.cz</a>
Result on the web
<a href="https://jlb.onlinelibrary.wiley.com/doi/full/10.1002/JLB.1AB0417-160RR" target="_blank" >https://jlb.onlinelibrary.wiley.com/doi/full/10.1002/JLB.1AB0417-160RR</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/JLB.1AB0417-160RR" target="_blank" >10.1002/JLB.1AB0417-160RR</a>
Alternative languages
Result language
angličtina
Original language name
The mannose 6-phosphate/insulin-like growth factor 2 receptor mediates plasminogen-induced efferocytosis
Original language description
The plasminogen system is harnessed in a wide variety of physiological processes, such as fibrinolysis, cell migration, or efferocytosis, and accordingly, it is essential upon inflammation, tissue remodeling, wound healing, and for homeostatic maintenance in general. Previously, we identified a plasminogen receptor in the mannose 6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R, CD222). Here, we demonstrate by means of genetic knockdown, knockout, and rescue approaches combined with functional studies that M6P/IGF2R is up-regulated on the surface of macrophages, recognizes plasminogen exposed on the surface of apoptotic cells, and mediates plasminogen-induced efferocytosis. The level of uptake of plasminogen-coated apoptotic cells inversely correlates with the TNF-alpha production by phagocytes indicating tissue clearance without inflammation by this mechanism. Our results reveal an up-to-now undetermined function of M6P/IGF2R in clearance of apoptotic cells, which is crucial for tissue homeostasis.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30102 - Immunology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Leukocyte Biology
ISSN
0741-5400
e-ISSN
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Volume of the periodical
105
Issue of the periodical within the volume
3
Country of publishing house
US - UNITED STATES
Number of pages
12
Pages from-to
519-530
UT code for WoS article
000459489900009
EID of the result in the Scopus database
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