Nucleoli in embryos: a central structural platform for embryonic chromatin remodeling?

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F19%3A00579085" target="_blank" >RIV/68378050:_____/19:00579085 - isvavai.cz</a>

Alternative codes found

RIV/68378041:_____/19:00517828 RIV/00027014:_____/19:N0000022

Result on the web

<a href="https://link.springer.com/article/10.1007/s10577-018-9590-3" target="_blank" >https://link.springer.com/article/10.1007/s10577-018-9590-3</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s10577-018-9590-3" target="_blank" >10.1007/s10577-018-9590-3</a>

Result language

angličtina

Original language name

Nucleoli in embryos: a central structural platform for embryonic chromatin remodeling?

Original language description

Nucleoli are the site of ribosomal RNA production and subunit assembly. In contrast to active nucleoli in somatic cells, where three basic sub-compartments can be observed, mammalian oocytes and early embryos contain atypical nucleoli termed nucleolus-like bodies or nucleolus precursor bodies, respectively. Unlike their somatic counterparts, these structures are composed of dense homogenous fibrillar material and exhibit no polymerase activity. Irrespective of these unusual properties, they have been shown to be absolutely essential for embryonic development, as their microsurgical removal results in developmental arrest. Historically, nucleolus-like and nucleolus precursor bodies have been perceived as passive storage sites of nucleolar material, which is gradually utilized by embryos to construct fully functional nucleoli once they have activated their genome and have started to produce ribosomes. For decades, researchers have been trying to elucidate the composition of these organelles and provide the evidence for their repository role. However, only recently has it become clear that the function of these atypical nucleoli is altogether different, and rather than being involved in ribosome biogenesis, they participate in parental chromatin remodeling, and strikingly, the artificial introduction of a single NPB component is sufficient to rescue the developmental arrest elicited by the NPB removal. In this review, we will describe and summarize the experiments that led to the change in our understanding of these unique structures.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10608 - Biochemistry and molecular biology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Chromosome Research

ISSN

0967-3849

e-ISSN

1573-6849

Volume of the periodical

27

Issue of the periodical within the volume

1-2

Country of publishing house

DE - GERMANY

Number of pages

12

Pages from-to

129-140

UT code for WoS article

000460114900011

EID of the result in the Scopus database

2-s2.0-85056171712