Pathogenic Potential of Hic1-Expressing Cardiac Stromal Progenitors

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F20%3A00531041" target="_blank" >RIV/68378050:_____/20:00531041 - isvavai.cz</a>

Result on the web

<a href="https://www.sciencedirect.com/journal/cell-stem-cell/vol/26/issue/2" target="_blank" >https://www.sciencedirect.com/journal/cell-stem-cell/vol/26/issue/2</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.stem.2019.12.008" target="_blank" >10.1016/j.stem.2019.12.008</a>

Result language

angličtina

Original language name

Pathogenic Potential of Hic1-Expressing Cardiac Stromal Progenitors

Original language description

The cardiac stroma contains multipotent mesenchymal progenitors. However, lineage relationships within cardiac stromal cells are poorly defined. Here, we identified heart-resident PDGFRa(+) SCA-1(+) cells as cardiac fibro/adipogenic progenitors (cFAPs) and show that they respond to ischemic damage by generating fibrogenic cells. Pharmacological blockade of this differentiation step with an anti-fibrotic tyrosine kinase inhibitor decreases post-myocardial infarction (post-MI) remodeling and leads to improvement in cardiac function. In the undamaged heart, activation of cFAPs through lineage-specific deletion of the gene encoding the quiescence-associated factor HIC1 reveals additional pathogenic potential, causing fibrofatty infiltration within the myocardium and driving major pathological features pathognomonic in arrhythmogenic cardiomyopathy (AC). In this regard, cFAPs contribute to multiple pathogenic cell types within cardiac tissue and therapeutic strategies aimed at modifying their activity are expected to have tremendous benefit for the treatment of diverse cardiac diseases.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10608 - Biochemistry and molecular biology

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Cell Stem Cell

ISSN

1934-5909

e-ISSN

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Volume of the periodical

26

Issue of the periodical within the volume

2

Country of publishing house

US - UNITED STATES

Number of pages

16

Pages from-to

205-220

UT code for WoS article

000512951100011

EID of the result in the Scopus database

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