The leucine zipper region of Myb oncoprotein regulates commitment of hematopoietic progenitors.

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F01%3A23010445" target="_blank" >RIV/68378050:_____/01:23010445 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

The leucine zipper region of Myb oncoprotein regulates commitment of hematopoietic progenitors.

Original language description

The development of blood cells proceeds from pluripotent stem cells through multipotent progenitors into mature cells belonging to at least eight different leneages. We found that the leucine zipper region (LZR) of the v-Myb transcription factor affets the lineage commitment of myeloid progenitors. We propose that Myb LZR can function as a molecular switch affecting expression of lineage specifying factors and directing the development of hematopoietic progenitors into either myeloid or erythroid lineages.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2001

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Blood

ISSN

0006-4971

e-ISSN

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Volume of the periodical

98

Issue of the periodical within the volume

N/A

Country of publishing house

US - UNITED STATES

Number of pages

9

Pages from-to

3668-3676

UT code for WoS article

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EID of the result in the Scopus database

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