SGIP1 is involved in regulation of emotionality, mood, and nociception and modulates in vivo signalling of cannabinoid CB1 receptors
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F21%3A00543888" target="_blank" >RIV/68378050:_____/21:00543888 - isvavai.cz</a>
Result on the web
<a href="https://bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15383" target="_blank" >https://bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15383</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/bph.15383" target="_blank" >10.1111/bph.15383</a>
Alternative languages
Result language
angličtina
Original language name
SGIP1 is involved in regulation of emotionality, mood, and nociception and modulates in vivo signalling of cannabinoid CB1 receptors
Original language description
Background and Purpose Src homology 3-domain growth factor receptor-bound 2-like endophilin interacting protein 1 (SGIP1) interacts with cannabinoid CB1 receptors. SGIP1 is abundantly and principally expressed within the nervous system. SGIP1 and CB1 receptors co-localize in axons and presynaptic boutons. SGIP1 interferes with the internalization of activated CB1 receptors in transfected heterologous cells. Consequently, the transient association of CB1 receptors with beta-arrestin2 is enhanced and prolonged, and CB1 receptor-mediated ERK1/2 signalling is decreased. Because of these actions, SGIP1 may modulate affect, anxiety, pain processing, and other physiological processes controlled by the endocannabinoid system (ECS).
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
British Journal of Pharmacology
ISSN
0007-1188
e-ISSN
1476-5381
Volume of the periodical
178
Issue of the periodical within the volume
7
Country of publishing house
GB - UNITED KINGDOM
Number of pages
17
Pages from-to
1588-1604
UT code for WoS article
000622421000001
EID of the result in the Scopus database
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