Disruption of paternal circadian rhythm affects metabolic health in male offspring via nongerm cell factors
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F21%3A00544146" target="_blank" >RIV/68378050:_____/21:00544146 - isvavai.cz</a>
Result on the web
<a href="https://advances.sciencemag.org/content/7/22/eabg6424" target="_blank" >https://advances.sciencemag.org/content/7/22/eabg6424</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1126/sciadv.abg6424" target="_blank" >10.1126/sciadv.abg6424</a>
Alternative languages
Result language
angličtina
Original language name
Disruption of paternal circadian rhythm affects metabolic health in male offspring via nongerm cell factors
Original language description
Circadian rhythm synchronizes each body function with the environment and regulates physiology. Disruption of normal circadian rhythm alters organismal physiology and increases disease risk. Recent epidemiological data and studies in model organisms have shown that maternal circadian disruption is important for offspring health and adult phenotypes. Less is known about the role of paternal circadian rhythm for offspring health. Here, we disrupted circadian rhythm in male mice by night-restricted feeding and showed that paternal circadian disruption at conception is important for offspring feeding behavior, metabolic health, and oscillatory transcription. Mechanistically, our data suggest that the effect of paternal circadian disruption is not transferred to the offspring via the germ cells but initiated by corticosterone-based parental communication at conception and programmed during in utero development through a state of fetal growth restriction. These findings indicate paternal circadian health at conception as a newly identified determinant of offspring phenotypes.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10602 - Biology (theoretical, mathematical, thermal, cryobiology, biological rhythm), Evolutionary biology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Science Advances
ISSN
2375-2548
e-ISSN
2375-2548
Volume of the periodical
7
Issue of the periodical within the volume
22
Country of publishing house
US - UNITED STATES
Number of pages
13
Pages from-to
eabg6424
UT code for WoS article
000655906900033
EID of the result in the Scopus database
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