Circadian alignment in a foster mother improves the offspring's pathological phenotype

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F18%3A00498578" target="_blank" >RIV/67985823:_____/18:00498578 - isvavai.cz</a>

Alternative codes found

RIV/00023752:_____/18:43919397

Result on the web

<a href="http://dx.doi.org/10.1113/JP275585" target="_blank" >http://dx.doi.org/10.1113/JP275585</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1113/JP275585" target="_blank" >10.1113/JP275585</a>

Result language

angličtina

Original language name

Circadian alignment in a foster mother improves the offspring's pathological phenotype

Original language description

In mammals, the mother-offspring interaction is essential for health later in adulthood. Maternal care is determined by the circadian phenotype of the mother. The impact of altered timing and quality of maternal care on the circadian system was assessed using a cross-strain fostering approach, with 'abnormal' (i.e. circadian misaligned) care being represented by spontaneously hypertensive rats (SHR) and 'normal' care by Wistar rats. The SHR mothers worsened synchrony of the central clock in the suprachiasmatic nuclei with the light/dark cycle in Wistar rat pups, although this effect disappeared after weaning. The maternal care provided by Wistar rat mothers to SHR pups facilitated the development of amplitudes of the Bmal1 expression rhythm in the suprachiasmatic nuclei of the hypothalamus, as well as the clock-driven activity/rest rhythm and its entrainment to the external light/dark cycle. The peripheral clocks in the liver and colon responded robustly to cross-strain fostering, the circadian phenotype of the Wistar rat foster mother remedied the dampened amplitudes of the colonic clock in SHR pups and improved their cardiovascular functions. In general, the more intensive maternal care of the Wistar rat mothers improved most of the parameters of the abnormal SHR circadian phenotype in adulthood, conversely, the less frequent maternal care of the SHR mothers worsened these parameters in the Wistar rat during the early developmental stages. Altogether, our data provide compelling evidence that the circadian phenotype of a foster mother may positively and negatively affect the regulatory mechanisms of various physiological parameters, even if the pathological symptoms are genetically programmed.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30105 - Physiology (including cytology)

Project

<a href="/en/project/GA16-03932S" target="_blank" >GA16-03932S: Mechanisms of maternal entrainment of the fetal circadian clocks in mammals</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Physiology

ISSN

0022-3751

e-ISSN

—

Volume of the periodical

596

Issue of the periodical within the volume

23

Country of publishing house

GB - UNITED KINGDOM

Number of pages

19

Pages from-to

5757-5775

UT code for WoS article

000451696700026

EID of the result in the Scopus database

2-s2.0-85046720987