Early Chronotype and Tissue-Specific Alterations of Circadian Clock Function in Spontaneously Hypertensive Rats

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F12%3A00381846" target="_blank" >RIV/67985823:_____/12:00381846 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1371/journal.pone.0046951" target="_blank" >http://dx.doi.org/10.1371/journal.pone.0046951</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1371/journal.pone.0046951" target="_blank" >10.1371/journal.pone.0046951</a>

Result language

angličtina

Original language name

Early Chronotype and Tissue-Specific Alterations of Circadian Clock Function in Spontaneously Hypertensive Rats

Original language description

The study analyzed the function of the circadian system of Spontaneously hypertensive rat (SHR). The results revealed that SHR exhibited an early chronotype, because the central clock in the suprachiasmaric nuclei of the hypothalamus was phase-advanced relative to light/dark cycle. Moreover, the output rhythm was dampened. The peripheral clocks of SHR reacted to the dampened central clock with tissue-specific consequences. In the colon, the rhythms were severely altered, whereas the effect was only marginal in the liver. These results might result in mutual desynchrony of circadian oscillators within the circadian system of SHR, thereby potentially contributing to metabolic pathology of the rat strain

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

ED - Physiology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

PLoS ONE

ISSN

1932-6203

e-ISSN

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Volume of the periodical

7

Issue of the periodical within the volume

10

Country of publishing house

US - UNITED STATES

Number of pages

14

Pages from-to

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UT code for WoS article

000309452600065

EID of the result in the Scopus database

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