Hybrid sterility genes in mice (Mus musculus): a peculiar case of PRDM9 incompatibility
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F21%3A00554554" target="_blank" >RIV/68378050:_____/21:00554554 - isvavai.cz</a>
Result on the web
<a href="https://www-cell-com.d360prx.biomed.cas.cz/trends/genetics/fulltext/S0168-9525(21)00164-5?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0168952521001645%3Fshowall%3Dtrue" target="_blank" >https://www-cell-com.d360prx.biomed.cas.cz/trends/genetics/fulltext/S0168-9525(21)00164-5?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0168952521001645%3Fshowall%3Dtrue</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.tig.2021.06.008" target="_blank" >10.1016/j.tig.2021.06.008</a>
Alternative languages
Result language
angličtina
Original language name
Hybrid sterility genes in mice (Mus musculus): a peculiar case of PRDM9 incompatibility
Original language description
Hybrid sterility is a critical step in the evolution of reproductive barriers between diverging taxa during the process of speciation. Recent studies of young subspecies of the house mouse revealed a multigenic nature and frequent polymorphism of hybrid sterility genes as well as the recurrent engagement of the meiosis-specific gene PR domain-containing 9 (Prdm9) and X-linked loci. Prdm9-controlled hybrid sterility is essentially chromosomal in nature, conditioned by the sequence divergence between subspecies. Depending on the Prdm9 interallelic interactions and the X-linked Hstx2 locus, the same homologs either regularly recombine and synapse, or show impaired DNA DSB repair, asynapsis, and early meiotic arrest. Thus, Prdm9-dependent hybrid sterility points to incompatibilities affecting meiotic recombination as a possible mechanism of reproductive isolation between (sub)species.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10603 - Genetics and heredity (medical genetics to be 3)
Result continuities
Project
<a href="/en/project/GA20-04075S" target="_blank" >GA20-04075S: The role of PRDM9-mediated synapsis of meiotic chromosomes in hybrid sterility</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Trends in Genetics
ISSN
0168-9525
e-ISSN
1362-4555
Volume of the periodical
37
Issue of the periodical within the volume
12
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
14
Pages from-to
1095-1108
UT code for WoS article
000718104000009
EID of the result in the Scopus database
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