Improved hematopoietic stem cell transplantation upon inhibition of natural killer cell-derived interferon-gamma
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F21%3A00555012" target="_blank" >RIV/68378050:_____/21:00555012 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11120/21:43921781 RIV/00216208:11110/21:10429136 RIV/00064165:_____/21:10429136 RIV/00216208:11130/21:10429136 RIV/00216208:11310/21:10429136
Result on the web
<a href="https://linkinghub.elsevier.com/retrieve/pii/S2213671121003143" target="_blank" >https://linkinghub.elsevier.com/retrieve/pii/S2213671121003143</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.stemcr.2021.06.008" target="_blank" >10.1016/j.stemcr.2021.06.008</a>
Alternative languages
Result language
angličtina
Original language name
Improved hematopoietic stem cell transplantation upon inhibition of natural killer cell-derived interferon-gamma
Original language description
Hematopoietic stem cell transplantation (HSCT) is a frequent therapeutic approach to restore hematopoiesis in patients with hematologic diseases. Patients receive a hematopoietic stem cell (HSC)-enriched donor cell infusion also containing immune cells, which may have a beneficial effect by eliminating residual neoplastic cells. However, the effect that donor innate immune cells may have on the donor HSCs has not been deeply explored. Here, we evaluate the influence of donor natural killer (NK) cells on HSC fate, concluded that NK cells negatively affect HSC frequency and function, and identified interferon-gamma (IFNg) as a potential mediator. Interestingly, improved HSC fitness was achieved by NK cell depletion from murine and human donor infusions or by blocking IFNg activity. Thus, our data suggest that suppression of inflammatory signals generated by donor innate immune cells can enhance engraftment and hematopoietic reconstitution during HSCT, which is particularly critical when limited HSC numbers are available and the risk of engraftment failure is high.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10601 - Cell biology
Result continuities
Project
<a href="/en/project/GA18-08577S" target="_blank" >GA18-08577S: The transcription factor C/EBPg as a novel regulator in mast cell development and function</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Stem Cell Reports
ISSN
2213-6711
e-ISSN
2213-6711
Volume of the periodical
16
Issue of the periodical within the volume
8
Country of publishing house
US - UNITED STATES
Number of pages
15
Pages from-to
1999-2013
UT code for WoS article
000684300500013
EID of the result in the Scopus database
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