Availability of Haematopoietic Niches for Transplanted Stem Cells

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F13%3A10189439" target="_blank" >RIV/00216208:11110/13:10189439 - isvavai.cz</a>

Result on the web

<a href="http://fb.cuni.cz/file/5666/FB2013A0001.pdf" target="_blank" >http://fb.cuni.cz/file/5666/FB2013A0001.pdf</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Availability of Haematopoietic Niches for Transplanted Stem Cells

Original language description

Following transplantation, donor haematopoietic stem cells (HSCs) must reach specific parts of haematopoietic stroma tissue known as stem cell niches to become engrafted and to start blood cell production. Regularly, they have to compete with the host'sHSCs for a limited number of niches. The exact mechanisms of HSC engraftment as well as of niche "opening" to incoming HSCs by conditioning treatments are not well-known yet. Significant and stable engraftment of syngeneic donor HSCs can be achieved in untreated mice only after transplantation of very large numbers of marrow cells. Engraftment can be largely facilitated by the stem cell mutations reducing numbers of the host HSCs. Pre-transplantation manipulations of the host haematopoietic tissue enhance engraftment depending on how much they damage HSCs. Ionizing radiation appears to be the most effective in this respect despite proliferative quiescence of a majority of HSCs. The review summarizes major achievements in deciphering bio

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

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Continuities

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Folia Biologica

ISSN

0015-5500

e-ISSN

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Volume of the periodical

59

Issue of the periodical within the volume

1

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

14

Pages from-to

1-14

UT code for WoS article

000326215200001

EID of the result in the Scopus database

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