Analysis of 5-Azacytidine Resistance Models Reveals a Set of Targetable Pathways
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F22%3A00557510" target="_blank" >RIV/68378050:_____/22:00557510 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/22:10442470 RIV/00064165:_____/22:10442470
Result on the web
<a href="https://www.mdpi.com/2073-4409/11/2/223" target="_blank" >https://www.mdpi.com/2073-4409/11/2/223</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/cells11020223" target="_blank" >10.3390/cells11020223</a>
Alternative languages
Result language
angličtina
Original language name
Analysis of 5-Azacytidine Resistance Models Reveals a Set of Targetable Pathways
Original language description
The mechanisms by which myelodysplastic syndrome (MDS) cells resist the effects of hypomethylating agents (HMA) are currently the subject of intensive research. A better understanding of mechanisms by which the MDS cell becomes to tolerate HMA and progresses to acute myeloid leukemia (AML) requires the development of new cellular models. From MDS/AML cell lines we developed a model of 5-azacytidine (AZA) resistance whose stability was validated by a transplantation approach into immunocompromised mice. When investigating mRNA expression and DNA variants of the AZA resistant phenotype we observed deregulation of several cancer-related pathways including the phosphatidylinosito-3 kinase signaling. We have further shown that these pathways can be modulated by specific inhibitors that, while blocking the proliferation of AZA resistant cells, are unable to increase their sensitivity to AZA. Our data reveal a set of molecular mechanisms that can be targeted to expand therapeutic options during progression on AZA therapy.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10601 - Cell biology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Cells
ISSN
2073-4409
e-ISSN
2073-4409
Volume of the periodical
11
Issue of the periodical within the volume
2
Country of publishing house
CH - SWITZERLAND
Number of pages
13
Pages from-to
223
UT code for WoS article
000757973600001
EID of the result in the Scopus database
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