Mitochondrial respiration supports autophagy to provide stress resistance during quiescence
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F22%3A00557875" target="_blank" >RIV/68378050:_____/22:00557875 - isvavai.cz</a>
Alternative codes found
RIV/86652036:_____/22:00557875 RIV/67985823:_____/22:00557875 RIV/00023001:_____/22:00083463 RIV/00216208:11310/22:10456185
Result on the web
<a href="https://www.tandfonline.com/doi/full/10.1080/15548627.2022.2038898" target="_blank" >https://www.tandfonline.com/doi/full/10.1080/15548627.2022.2038898</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1080/15548627.2022.2038898" target="_blank" >10.1080/15548627.2022.2038898</a>
Alternative languages
Result language
angličtina
Original language name
Mitochondrial respiration supports autophagy to provide stress resistance during quiescence
Original language description
Mitochondrial oxidative phosphorylation (OXPHOS) generates ATP, but OXPHOS also supports biosynthesis during proliferation. In contrast, the role of OXPHOS during quiescence, beyond ATP production, is not well understood. Using mouse models of inducible OXPHOS deficiency in all cell types or specifically in the vascular endothelium that negligibly relies on OXPHOS-derived ATP, we show that selectively during quiescence OXPHOS provides oxidative stress resistance by supporting macroautophagy/autophagy. Mechanistically, OXPHOS constitutively generates low levels of endogenous ROS that induce autophagy via attenuation of ATG4B activity, which provides protection from ROS insult. Physiologically, the OXPHOS-autophagy system (i) protects healthy tissue from toxicity of ROS-based anticancer therapy, and (ii) provides ROS resistance in the endothelium, ameliorating systemic LPS-induced inflammation as well as inflammatory bowel disease. Hence, cells acquired mitochondria during evolution to profit from oxidative metabolism, but also built in an autophagy-based ROS-induced protective mechanism to guard against oxidative stress associated with OXPHOS function during quiescence.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10601 - Cell biology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Autophagy
ISSN
1554-8627
e-ISSN
1554-8635
Volume of the periodical
18
Issue of the periodical within the volume
10
Country of publishing house
US - UNITED STATES
Number of pages
19
Pages from-to
2409-2426
UT code for WoS article
000766134900001
EID of the result in the Scopus database
2-s2.0-85126384039