Mitochondria-driven elimination of cancer and senescent cells

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F86652036%3A_____%2F19%3A00520732" target="_blank" >RIV/86652036:_____/19:00520732 - isvavai.cz</a>
Result on the web
<a href="https://www.nature.com/articles/s41418-018-0118-3" target="_blank" >https://www.nature.com/articles/s41418-018-0118-3</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1515/hsz-2018-0256" target="_blank" >10.1515/hsz-2018-0256</a>

Result language
angličtina
Original language name
Mitochondria-driven elimination of cancer and senescent cells
Original language description
Mitochondria and oxidative phosphorylation (OXPHOS) are emerging as intriguing targets for the efficient elimination of cancer cells. The specificity of this approach is aided by the capacity of non-proliferating non-cancerous cells to withstand oxidative insult induced by OXPHOS inhibition. Recently we discovered that mitochondrial targeting can also be employed to eliminate senescent cells, where it breaks the interplay between OXPHOS and ATP transporters that appear important for the maintenance of mitochondrial morphology and viability in the senescent setting. Hence, mitochondria/OXPHOS directed pharmacological interventions show promise in several clinically-relevant scenarios that call for selective removal of cancer and senescent cells.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10608 - Biochemistry and molecular biology

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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