Comprehensive Transcriptional Profiling and Mouse Phenotyping Reveals Dispensable Role for Adipose Tissue Selective Long Noncoding RNA Gm15551

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F22%3A00558861" target="_blank" >RIV/68378050:_____/22:00558861 - isvavai.cz</a>

Result on the web

<a href="https://www.mdpi.com/2311-553X/8/3/32" target="_blank" >https://www.mdpi.com/2311-553X/8/3/32</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/ncrna8030032" target="_blank" >10.3390/ncrna8030032</a>

Result language

angličtina

Original language name

Comprehensive Transcriptional Profiling and Mouse Phenotyping Reveals Dispensable Role for Adipose Tissue Selective Long Noncoding RNA Gm15551

Original language description

Cold and nutrient-activated brown adipose tissue (BAT) is capable of increasing systemic energy expenditure via the uncoupled respiration and secretion of endocrine factors, thereby protecting mice against diet-induced obesity and improving insulin response and glucose tolerance in men. Long non-coding RNAs (lncRNAs) have recently been identified as fine-tuning regulators of cellular function. While certain lncRNAs have been functionally characterised in adipose tissue, their overall contribution in the activation of BAT remains elusive. We identified lncRNAs correlating to interscapular brown adipose tissue (iBAT) function in a high fat diet (HFD) and cold stressed mice. We focused on Gm15551, which has an adipose tissue specific expression profile, is highly upregulated during adipogenesis, and downregulated by beta-adrenergic activation in mature adipocytes. Although we performed comprehensive transcriptional and adipocyte physiology profiling in vitro and in vivo, we could not detect an effect of gain or loss of function of Gm15551.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10608 - Biochemistry and molecular biology

Project

<a href="/en/project/LM2018126" target="_blank" >LM2018126: Czech Centre for Phenogenomics</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Non-coding RNA

ISSN

2311-553X

e-ISSN

2311-553X

Volume of the periodical

8

Issue of the periodical within the volume

3

Country of publishing house

CH - SWITZERLAND

Number of pages

19

Pages from-to

32

UT code for WoS article

000816085400001

EID of the result in the Scopus database

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