FBXO38 Ubiquitin Ligase Controls Centromere Integrity via ZXDA/B Stability
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F22%3A00559232" target="_blank" >RIV/68378050:_____/22:00559232 - isvavai.cz</a>
Result on the web
<a href="https://www.frontiersin.org/articles/10.3389/fcell.2022.929288/full" target="_blank" >https://www.frontiersin.org/articles/10.3389/fcell.2022.929288/full</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3389/fcell.2022.929288" target="_blank" >10.3389/fcell.2022.929288</a>
Alternative languages
Result language
angličtina
Original language name
FBXO38 Ubiquitin Ligase Controls Centromere Integrity via ZXDA/B Stability
Original language description
Alterations in the gene encoding the E3 ubiquitin ligase substrate receptor FBXO38 have been associated with several diseases, including early-onset motor neuronopathy. However, the cellular processes affected by the enzymatic action of FBXO38 are not yet known. Here, we identify the zinc finger proteins ZXDA/B as its interaction partners. FBXO38 controls the stability of ZXDA/B proteins via ubiquitination and proteasome-dependent degradation. We show that ZXDA/B proteins associate with the centromeric protein CENP-B and that the interaction between ZXDA/B and FBXO38 or CENP-B is mutually exclusive. Functionally, ZXDA/B factors control the protein level of chromatin-associated CENP-B. Furthermore, their inappropriate stabilization leads to upregulation of CENP-A and CENP-B positive centromeric chromatin. Thus we demonstrate a previously unknown role of cullin-dependent protein degradation in the control of centromeric chromatin integrity.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10601 - Cell biology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Frontiers in Cell and Developmental Biology
ISSN
2296-634X
e-ISSN
2296-634X
Volume of the periodical
10
Issue of the periodical within the volume
June
Country of publishing house
CH - SWITZERLAND
Number of pages
16
Pages from-to
929288
UT code for WoS article
000821850900001
EID of the result in the Scopus database
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