FBXO38 is dispensable for PD-1 regulation
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F24%3A00599981" target="_blank" >RIV/68378050:_____/24:00599981 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/24:10487496
Result on the web
<a href="https://www.embopress.org/doi/full/10.1038/s44319-024-00220-8" target="_blank" >https://www.embopress.org/doi/full/10.1038/s44319-024-00220-8</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s44319-024-00220-8" target="_blank" >10.1038/s44319-024-00220-8</a>
Alternative languages
Result language
angličtina
Original language name
FBXO38 is dispensable for PD-1 regulation
Original language description
SKP1-CUL1-F-box protein (SCF) ubiquitin ligases are versatile protein complexes that mediate the ubiquitination of protein substrates. The direct substrate recognition relies on a large family of F-box-domain-containing subunits. One of these substrate receptors is FBXO38, which is encoded by a gene found mutated in families with early-onset distal motor neuronopathy. SCFFBXO38 ubiquitin ligase controls the stability of ZXDB, a nuclear factor associated with the centromeric chromatin protein CENP-B. Loss of FBXO38 in mice results in growth retardation and defects in spermatogenesis characterized by deregulation of the Sertoli cell transcription program and compromised centromere integrity. Moreover, it was reported that SCFFBXO38 mediates the degradation of PD-1, a key immune-checkpoint inhibitor in T cells. Here, we have re-addressed the link between SCFFBXO38 and PD-1 proteolysis. Our data do not support the notion that SCFFBXO38 directly or indirectly controls the abundance and stability of PD-1 in T cells.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30102 - Immunology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Embo Reports
ISSN
1469-221X
e-ISSN
1469-3178
Volume of the periodical
25
Issue of the periodical within the volume
10
Country of publishing house
US - UNITED STATES
Number of pages
20
Pages from-to
4206-4225
UT code for WoS article
001312686300001
EID of the result in the Scopus database
2-s2.0-85203847699