Trilateral interaction between innervation, leukocyte, and adventitia: a new driver of atherosclerotic plaque formation
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F22%3A00569108" target="_blank" >RIV/68378050:_____/22:00569108 - isvavai.cz</a>
Result on the web
<a href="https://www.nature.com/articles/s41392-022-01121-9" target="_blank" >https://www.nature.com/articles/s41392-022-01121-9</a>
DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Trilateral interaction between innervation, leukocyte, and adventitia: a new driver of atherosclerotic plaque formation
Original language description
This research highlight focuses on the recent discovery of crosstalk between arteries, the nervous system, and the immune system in atherosclerosis. Data show that although atherosclerotic plaques are not innervated, axon density in the plaque regions is much higher compared to the plaque-free areas. Under stress conditions, cooperation of the neuronal and immune systems brings into plaques immune cells. The data highlight the neuroimmunological approach as a tool to prevent and treat vascular inflammation and plaque formation.
Czech name
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Czech description
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Classification
Type
O - Miscellaneous
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2022
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů