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Identification of GC-rich LAT genes in birds

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F23%3A00572429" target="_blank" >RIV/68378050:_____/23:00572429 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216208:11310/23:10470737

  • Result on the web

    <a href="https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0283431" target="_blank" >https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0283431</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1371/journal.pone.0283431" target="_blank" >10.1371/journal.pone.0283431</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Identification of GC-rich LAT genes in birds

  • Original language description

    Linker for activation of T cells (LAT) plays a key role in T-cell antigenic signaling in mammals. Accordingly, LAT orthologues were identified in the majority of vertebrates. However, LAT orthologues were not identified in most birds. In this study, we show that LAT gene is present in genomes of multiple extant birds. It was not properly assembled previously because of its GC-rich content. LAT expression is enriched in lymphoid organs in chicken. The analysis of the coding sequences revealed a strong conservation of key signaling motifs in LAT between chicken and human. Overall, our data indicate that mammalian and avian LAT genes are functional homologues with a common role in T-cell signaling.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10608 - Biochemistry and molecular biology

Result continuities

  • Project

    <a href="/en/project/LX22NPO5103" target="_blank" >LX22NPO5103: National Institute of Virology and Bacteriology</a><br>

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2023

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    PLoS ONE

  • ISSN

    1932-6203

  • e-ISSN

    1932-6203

  • Volume of the periodical

    18

  • Issue of the periodical within the volume

    4

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    8

  • Pages from-to

    e0283431

  • UT code for WoS article

    000969434300008

  • EID of the result in the Scopus database

    2-s2.0-85151803411