Identification of GC-rich LAT genes in birds
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F23%3A00572429" target="_blank" >RIV/68378050:_____/23:00572429 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/23:10470737
Result on the web
<a href="https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0283431" target="_blank" >https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0283431</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1371/journal.pone.0283431" target="_blank" >10.1371/journal.pone.0283431</a>
Alternative languages
Result language
angličtina
Original language name
Identification of GC-rich LAT genes in birds
Original language description
Linker for activation of T cells (LAT) plays a key role in T-cell antigenic signaling in mammals. Accordingly, LAT orthologues were identified in the majority of vertebrates. However, LAT orthologues were not identified in most birds. In this study, we show that LAT gene is present in genomes of multiple extant birds. It was not properly assembled previously because of its GC-rich content. LAT expression is enriched in lymphoid organs in chicken. The analysis of the coding sequences revealed a strong conservation of key signaling motifs in LAT between chicken and human. Overall, our data indicate that mammalian and avian LAT genes are functional homologues with a common role in T-cell signaling.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
<a href="/en/project/LX22NPO5103" target="_blank" >LX22NPO5103: National Institute of Virology and Bacteriology</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
PLoS ONE
ISSN
1932-6203
e-ISSN
1932-6203
Volume of the periodical
18
Issue of the periodical within the volume
4
Country of publishing house
US - UNITED STATES
Number of pages
8
Pages from-to
e0283431
UT code for WoS article
000969434300008
EID of the result in the Scopus database
2-s2.0-85151803411