Dicer structure and function: conserved and evolving features
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F23%3A00573993" target="_blank" >RIV/68378050:_____/23:00573993 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14740/23:00132893
Result on the web
<a href="https://www.embopress.org/doi/epdf/10.15252/embr.202357215" target="_blank" >https://www.embopress.org/doi/epdf/10.15252/embr.202357215</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.15252/embr.202357215" target="_blank" >10.15252/embr.202357215</a>
Alternative languages
Result language
angličtina
Original language name
Dicer structure and function: conserved and evolving features
Original language description
RNase III Dicer produces small RNAs guiding sequence-specific regulations, with important biological roles in eukaryotes. Major Dicer-dependent mechanisms are RNA interference (RNAi) and microRNA (miRNA) pathways, which employ distinct types of small RNAs. Small interfering RNAs (siRNAs) for RNAi are produced by Dicer from long double-stranded RNA (dsRNA) as a pool of different small RNAs. In contrast, miRNAs have specific sequences because they are precisely cleaved out from small hairpin precursors. Some Dicer homologs efficiently generate both, siRNAs and miRNAs, while others are adapted for biogenesis of one small RNA type. Here, we review the wealth of recent structural analyses of animal and plant Dicers, which have revealed how different domains and their adaptations contribute to substrate recognition and cleavage in different organisms and pathways. These data imply that siRNA generation was Dicer's ancestral role and that miRNA biogenesis relies on derived features. While the key element of functional divergence is a RIG-I-like helicase domain, Dicer-mediated small RNA biogenesis also documents the impressive functional versatility of the dsRNA-binding domain.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
<a href="/en/project/GX20-03950X" target="_blank" >GX20-03950X: In vivo mammalian RNAi revival</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Embo Reports
ISSN
1469-221X
e-ISSN
1469-3178
Volume of the periodical
24
Issue of the periodical within the volume
7
Country of publishing house
US - UNITED STATES
Number of pages
13
Pages from-to
e57215
UT code for WoS article
001005196500001
EID of the result in the Scopus database
2-s2.0-85163079168