IL-2-driven CD8+ T cell phenotypes: implications for immunotherapy
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F23%3A00578373" target="_blank" >RIV/68378050:_____/23:00578373 - isvavai.cz</a>
Alternative codes found
RIV/61388971:_____/23:00578373
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S1471490623001953?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1471490623001953?via%3Dihub</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.it.2023.09.003" target="_blank" >10.1016/j.it.2023.09.003</a>
Alternative languages
Result language
angličtina
Original language name
IL-2-driven CD8+ T cell phenotypes: implications for immunotherapy
Original language description
The therapeutic potential of interleukin (IL)-2 in cancer treatment has been known for decades, yet its widespread adoption in clinical practice remains limited. Recently, chimeric proteins of an anti-PD-1 antibody and suboptimal IL-2 variants were shown to stimulate potent antitumor and antiviral immunity by inducing unique effector CD8+ T cells in mice. A similar subset of cytotoxic T cells is induced by depletion of regulatory T cells (Tregs), suggesting IL-2 sequestration as a major mechanism through which regulatory T cells suppress activated CD8+ T cells. Here, we present our view of how IL-2-based biologicals can boost the antitumor response at a cellular level, and propose that the role of Tregs following such treatments may have been previously overestimated.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30102 - Immunology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Trends in Immunology
ISSN
1471-4906
e-ISSN
1471-4981
Volume of the periodical
44
Issue of the periodical within the volume
11
Country of publishing house
GB - UNITED KINGDOM
Number of pages
12
Pages from-to
890-901
UT code for WoS article
001101620100001
EID of the result in the Scopus database
2-s2.0-85173934074