Omega-3 PUFAs prevent bone impairment and bone marrow adiposity in mouse model of obesity
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F23%3A00579053" target="_blank" >RIV/68378050:_____/23:00579053 - isvavai.cz</a>
Alternative codes found
RIV/67985823:_____/23:00579053 RIV/00216208:11310/23:10477274
Result on the web
<a href="https://doi.org/10.1038/s42003-023-05407-8" target="_blank" >https://doi.org/10.1038/s42003-023-05407-8</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s42003-023-05407-8" target="_blank" >10.1038/s42003-023-05407-8</a>
Alternative languages
Result language
angličtina
Original language name
Omega-3 PUFAs prevent bone impairment and bone marrow adiposity in mouse model of obesity
Original language description
Obesity adversely affects bone and fat metabolism in mice and humans. Omega-3 polyunsaturated fatty acids (omega-3 PUFAs) have been shown to improve glucose metabolism and bone homeostasis in obesity. However, the impact of omega-3 PUFAs on bone marrow adipose tissue (BMAT) and bone marrow stromal cell (BMSC) metabolism has not been intensively studied yet. In the present study we demonstrated that omega-3 PUFA supplementation in high fat diet (HFD + F) improved bone parameters, mechanical properties along with decreased BMAT in obese mice when compared to the HFD group. Primary BMSCs isolated from HFD + F mice showed decreased adipocyte and higher osteoblast differentiation with lower senescent phenotype along with decreased osteoclast formation suggesting improved bone marrow microenvironment promoting bone formation in mice. Thus, our study highlights the beneficial effects of omega-3 PUFA-enriched diet on bone and cellular metabolism and its potential use in the treatment of metabolic bone diseases.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10601 - Cell biology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Communications Biology
ISSN
2399-3642
e-ISSN
2399-3642
Volume of the periodical
6
Issue of the periodical within the volume
1
Country of publishing house
GB - UNITED KINGDOM
Number of pages
17
Pages from-to
1043
UT code for WoS article
001086579600001
EID of the result in the Scopus database
2-s2.0-85174275716