NOX4-reactive oxygen species axis: critical regulators of bone health and metabolism
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F24%3A00597872" target="_blank" >RIV/67985823:_____/24:00597872 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11310/24:10497349
Result on the web
<a href="https://doi.org/10.3389/fcell.2024.1432668" target="_blank" >https://doi.org/10.3389/fcell.2024.1432668</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3389/fcell.2024.1432668" target="_blank" >10.3389/fcell.2024.1432668</a>
Alternative languages
Result language
angličtina
Original language name
NOX4-reactive oxygen species axis: critical regulators of bone health and metabolism
Original language description
Bone marrow stromal cells (BMSCs) play a significant role in bone metabolism as they can differentiate into osteoblasts, bone marrow adipocytes (BMAds), and chondrocytes. BMSCs chronically exposed to nutrient overload undergo adipogenic programming, resulting in bone marrow adipose tissue (BMAT) formation. BMAT is a fat depot transcriptionally, metabolically, and morphologically distinct from peripheral adipose depots. Reactive oxygen species (ROS) are elevated in obesity and serve as important signals directing BMSC fate. ROS produced by the NADPH oxidase (NOX) family of enzymes, such as NOX4, may be responsible for driving BMSC adipogenesis at the expense of osteogenic differentiation. The dual nature of ROS as both cellular signaling mediators and contributors to oxidative stress complicates their effects on bone metabolism. This review discusses the complex interplay between ROS and BMSC differentiation in the context of metabolic bone diseases.Special attention is paid to the role of NOX4-ROS in regulating cellular processes within the bone marrow microenvironment and potential target in metabolic bone diseases.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10601 - Cell biology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Frontiers in Cell and Developmental Biology
ISSN
2296-634X
e-ISSN
2296-634X
Volume of the periodical
12
Issue of the periodical within the volume
12 AUG
Country of publishing house
CH - SWITZERLAND
Number of pages
11
Pages from-to
1432668
UT code for WoS article
001297195900001
EID of the result in the Scopus database
2-s2.0-85201981195