Improving reproducibility and translational potential of mouse models: lessons from studying leishmaniasis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F25%3A00619637" target="_blank" >RIV/68378050:_____/25:00619637 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11120/25:43928398
Result on the web
<a href="https://doi.org/10.3389/fimmu.2025.1559907" target="_blank" >https://doi.org/10.3389/fimmu.2025.1559907</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3389/fimmu.2025.1559907" target="_blank" >10.3389/fimmu.2025.1559907</a>
Alternative languages
Result language
angličtina
Original language name
Improving reproducibility and translational potential of mouse models: lessons from studying leishmaniasis
Original language description
Leishmaniasis is a complex disease caused by protozoan parasites of the genus Leishmania, which are transmitted by phlebotomine sand flies. The clinical manifestations of leishmaniasis are diverse, ranging from self-healing cutaneous lesions to fatal systemic disease. Mouse models are instrumental in advancing our understanding of the immune system against infections, yet their limitations in translating findings to humans are increasingly highlighted. The success rate of translating data from mice to humans remains low, largely due to the complexity of diseases and the numerous factors that influence the disease outcomes. Therefore, for the effective translation of data from murine models of leishmaniasis, it is essential to align experimental conditions with those relevant to human infection. Factors such as parasite characteristics, vector-derived components, host status, and environmental conditions must be carefully considered and adapted to enhance the translational relevance of mouse data. These parameters are potentially modifiable and should be carefully integrated into the design and interpretation of experimental procedures in Leishmania studies. In the current paper, we review the challenges and perspective of using mouse as a model for leishmaniasis. We have particularly emphasized the non-genetic factors that influence experiments and focused on strategies to improve translational value of studies on leishmaniasis using mouse models.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30102 - Immunology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Frontiers in Immunology
ISSN
1664-3224
e-ISSN
1664-3224
Volume of the periodical
16
Issue of the periodical within the volume
22 Apr
Country of publishing house
CH - SWITZERLAND
Number of pages
17
Pages from-to
1559907
UT code for WoS article
001481553300001
EID of the result in the Scopus database
2-s2.0-105004412312