SWITCHER, a CRISPR-inducible floxed wild-type Cre regulating CRISPR activity

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F25%3A00637393" target="_blank" >RIV/68378050:_____/25:00637393 - isvavai.cz</a>
Alternative codes found
RIV/60162694:G33__/25:N0000001
Result on the web
<a href="https://doi.org/10.1038/s42003-025-08427-8" target="_blank" >https://doi.org/10.1038/s42003-025-08427-8</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s42003-025-08427-8" target="_blank" >10.1038/s42003-025-08427-8</a>

Result language
angličtina
Original language name
SWITCHER, a CRISPR-inducible floxed wild-type Cre regulating CRISPR activity
Original language description
Although several Cre-regulated CRISPR/Cas platforms exist, a CRISPR/Cas-controlled Cre-system remains a challenge. Here, we present a genetic switch we term SWITCHER based on a floxed wild-type Cre-construct representing a CRISPR-inducible and self-limiting kill switch. By leveraging CRISPR/Cas12a-mediated crRNA-array maturation, we showcase SWITCHER's dual role-not just as a recombinase but as a CRISPR switch, capable of orchestrating distinct Cas12a/crRNA-encoded programs.
Czech name
—
Czech description
—

Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
10608 - Biochemistry and molecular biology

Project
—
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)