Gamma smooth muscle actin as a new potential marker of cancer-associated fibroblasts
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378050%3A_____%2F25%3A00639471" target="_blank" >RIV/68378050:_____/25:00639471 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11110/25:10503156 RIV/00064165:_____/25:10503156
Result on the web
<a href="https://doi.org/10.1007/s00418-025-02419-9" target="_blank" >https://doi.org/10.1007/s00418-025-02419-9</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00418-025-02419-9" target="_blank" >10.1007/s00418-025-02419-9</a>
Alternative languages
Result language
angličtina
Original language name
Gamma smooth muscle actin as a new potential marker of cancer-associated fibroblasts
Original language description
Cancer-associated fibroblasts (CAFs) represent an important component of the cancer ecosystem, influencing the broad scale of biological properties of tumour cells, including the capacity for metastasis formation. An important CAF subpopulation, known as myCAFs, typically expresses alpha-smooth muscle actin. Transcriptomic analysis demonstrated that activated fibroblasts isolated from various pathological tissues also express the ACTG2 gene encoding gamma-smooth muscle actin. This was further validated by immunocytochemistry. Using the scratch test in vitro, it was possible to demonstrate that gamma-smooth muscle actin may be associated with the epithelial-mesenchymal transition, which was also shown by transcriptomic analysis. The presence of gamma-smooth muscle actin-positive fibroblasts in histopathological sections of human tumours verified the expression of this protein as a new potential marker of CAFs.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2025
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Histochemistry and Cell Biology
ISSN
0948-6143
e-ISSN
1432-119X
Volume of the periodical
163
Issue of the periodical within the volume
1
Country of publishing house
DE - GERMANY
Number of pages
16
Pages from-to
93
UT code for WoS article
001574661500001
EID of the result in the Scopus database
2-s2.0-105016598759